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Research

Current Projects

Department of Medical Statistics

Further methodological projects

  • DRGmodify - Modifications of DRGs for reimbursing health care services in hospitals (funded by BMBF)
    Collaboration with Cologne Merheim Hospital, Department of Pneumology, Kliniken der Stadt Köln; Pl: Prof Tim Mathes Department of Medical Statistics, University Medical Center Göttingen; Project duration: 2024-2025
  • KISSKI - Research on AI methods and their provision with the aim of enabling a highly available AI service centre for critical and sensitive infrastructures, with a focus on the fields of medicine and energy (funded by BMBF)
    Collaboration with Georg-August-University Göttingen; PI Prof Dr Julian Martin Kunkel, Institute of Computer Science, Georg-August-University Göttingen

Further projects by clinical subjects

Neurology

  • NOPARK - a phase III trial of nicotinamide riboside in Parkinson's disease (funded by KLINBEFORSK, Norway)
    Collaboration with Helse Bergen - Haukeland University Hospital; PI: Prof. Charalampos Tzoulis, Department of Neurology, Haukeland University Hospital
  • NADAPT - a randomized double-blind trial of NAD replenishment therapy for atypical parkinsonism (funded by KLINBEFORSK and Helse Vest, Norway)
    Collaboration with Helse Bergen - Haukeland University Hospital; PI: Prof. Charalampos Tzoulis, Department of Neurology, Haukeland University Hospital
  • ELEVIDA - Real-World Clinical Trial of an Online Cognitive Behavioral Therapy for Managing Fatigue in Multiple Sclerosis (funded by the Department of Defense office of the Congressionally Directed Medical Research Programs (CDMRP))
    Collaboration with Accelerated Cure Project, Inc. and the Department of Psychiatry, Charité Berlin; PI: Robert McBurney, Accelerated Cure Project, Inc.
  • PRO-DLB - Early identification and phenotyping of prodromal dementia with Lewy bodies via established and novel biomarkers (funded by DFG)
    Collaboration with Department of Psychiatry and Psychotherapy, University Medical Center Göttingen; Pl: PD Niels Hansen, Department of Psychiatry and Psychotherapy, University Medical Center Göttingen
  • MitoFolat - Folinic acid therapy in patients with Kearns-Sayre syndrome (KSS) and cerebral folate deficiency (funded by DFG)
    (Department of Medical Statistics | Clinical Trial Unit UMG) Collaboration with the Clinic for Paediatrics and Adolescent Medicine, University Medical Center Göttingen; PI: Prof Jutta Gärtner, Clinic for Paediatrics and Adolescent Medicine, University Medical Center Göttingen
  • Vorino-Stat – Multicenter Open Phase Ib Dose Escalation Study and Dose Confirmation Study on Tolerance and Safety of N-hydroxy-N'-phenyl-octanediamide in Patients with Mild Alzheimer’s Disease (funded by Alzheimer Stiftung Göttingen)
    Collaboration with the German Center for Neurodegenerative Diseases (DZNE)
  • EmBioProMS - Explorative Study of Emerging Blood Biomarkers in Progressive Multiple Sclerosis (funded by DMSG)
    Collaboration with the Neurology Clinic, RKU and the Clinic for Neurology in Dietenbronn; PI: Dr Ahmed Abdelhak, Neurology Clinic, RKU and Prof Hayrettin Tumani; Clinic for Neurology in Dietenbronn
  • SIMCODE - Simvastatin Add-on to Escitalopram in Patients with Comorbid Obesity and Major Depression: A Randomized Controlled Trial (funded by BMBF)
    Collaboration with the Charité Berlin; PI: Prof Christian Otte, Department of Psychiatry and Psychotherapy of the Charité Berlin

Cardiology

  • FLOTO-MRT – Multicentric Al development for cardiovascular disease classification and therapy support based on imaging data (funded by DZHK)
    Collaboration with Heidelberg University Hospital, University Hospital of Goethe University Rhein Main and Deutsches Herzzentrum der Charité Berlin
  • CABA HFpEF – Catheter-based ablation of atrial fibrillation vs. conventional treatment in patients with heart failure with preserved ejection (funded by DZHK)
    Collaboration with Charité Berlin; Pl: Prof Burkert Pieske, Medical Department, Division of Cardiology, Charité University Medicine Berlin
  • BioVAT-HF - Safety and Efficacy of Induced Pluripotent Stem Cell-derived Engineered Human Myocardium as Biological Ventricular Assist Device in Terminal Heart Failure (funded by DZHK)
    Collaboration with the Institute of Pharmacology and Toxicology of the University Medical Center Göttingen; PI: , Prof Wolfram-Hubertus Zimmermann, Institute of Pharmacology and Toxicology of the University Medical Center Göttingen
  • Reduce MFA - Effect of anti-fibrotic therapy on regression of myocardial fibrosis after transcatheter aortic valve implantation (TAVI) in aortic stenosis patients with high fibrotic burden (funded by DZHK)
    Collaboration with the Department of Cardiology and Pneumology, University Medical Center Göttingen; PIs: Prof Puls and Prof Zeisberg, Department of Cardiology and Pneumology, University Medical Center Göttingen
  • VAD-Trial - Early Versus Emergency Left Ventricular Assist Device Implantation in Patients Awaiting Cardiac Transplantation and Reg-VAD - Prospective, Observational, Multicentre Registry of Patients Eligible for the VAD Trial who Chose not to Participate in the Intervention Trial (funded by DZHK)
    Collaboration with the German Center for Cardiovascular Research (DZHK); PIs: Prof Volkmar Falk and PD Dr. Christoph Knosalla from the German Heart Institute (DHZB) Berlin; Prof Gerd Hasenfuß, Heart Center Göttingen and Prof Tim Friede, Department of Medical Statistics of the University Medical Center Göttingen [more information]
  • TransitionCHF Systolic Dysfunction to Congestive Heart Failure - Cohort Study (funded by DZHK)
    Collaboration with the Institute of Research on Myocardial Infarction (IHF GmbH) and the German Center for Cardiovascular Research (DZHK); PIs: Prof Gerd Hasenfuß, Prof Rolf Wachter and PD Dr. Frank Edelmann, Heart Center Göttingen, University Medical Center Göttingen [more information]
  • SPIRIT-HF - SPIRonolactone In the Treatment of Heart Failure (funded by DZHK)
    Collaboration with the Medical Department, Division of Cardiology, Charité University Medicine Berlin; PIs: Prof Burkert Pieske and PD Frank Edelman, Medical Department, Division of Cardiology, Charité University Medicine Berlin [more information]
  • RESHAPE-HF2 Trial - Randomised Investigation of the Mitraclip Device in Heart Failure: 2nd Trial in Patients with Clinically Significant Functional Mitral Regurgitation (funded by Industry)
    Collaboration with the Department of Innovative Clinical Trials, Heart Center of the University Medical Center Göttingen; PIs: Prof Wolfgang Schillinger, HELIOS Hospital Group and Prof Stefan Anker, Department of Innovative Clinical Trials, Heart Center of the University Medical Center Göttingen
  • FAIR-HF2 - Intravenous Iron in Patients with Systolic Heart Failure and Iron Deficiency to Improve Morbidity & Mortality (funded by DZHK)
    Collaboration with the Department of Innovative Clinical Trials, Heart Center of the University Medical Center Göttingen; PI: Prof Stefan Anker, Department of Innovative Clinical Trials of the University Medical Center Göttingen [more information]
  • CLOSURE-AF - Left Atrial Appendage CLOSURE in Patients with Atrial Fibrillation at High Risk of Stroke and Bleeding Compared to Medical Therapy: A Prospective Randomized Clinical Trial (funded by DZHK)
    Collaboration with the Department of Cardiology, Charité Berlin; PI: Prof Ulf Landmesser, Department of Cardiology, Charité Berlin [more information]
  • DEDICATE - Randomized, Multi-Center, Event-Driven Trial of TAVI versus SAVR in Patients with Symptomatic Severe Aortic Valve Stenosis and Intermediate Risk of Mortality, as assessed by STS-Score (funded by DZHK)
    Sponsor Institution: University Medical Center Hamburg-Eppendorf (UKE); PIs: Prof Blankenberg, University Heart & Vascular Center Hamburg and Prof Cremer, Clinic for Cardiovascular Surgery, UKSH

Oncology

  • ACO/ARO/AIO-18.1 - Preoperative Oxaliplatin-based Chemoradiotherapy and Consolidation Chemotherapy Versus Fluorouracil-based Chemoradiotherapy for MRI-defined Intermediate and High-risk Rectal Cancer Patients (funded by DKH)
    Collaboration with the Department of Radiation Therapy and Oncology, University Hospital Frankfurt/Main; PI: Prof Claus Rödel, Department of Radiation Therapy and Oncology, University Hospital Frankfurt/Mai
  • ACO/ARO/AIO-18.2 - Preoperative FOLFOX Versus Postoperative Risk-adapted Chemotherapy in Patients With Locally Advanced Rectal Cancer (funded by DKH)
    Collaboration with the University Medical Center Mannheim; PI: Prof. Hofheinz, Mannheim Cancer Center
  • CABONEN – a phase II trial of Cabozantinib in patients with advanced, low proliferative NEN G3 (funded by Industry)
    (Department of Medical Statistics | Clinical Trial Unit UMG) Collaboration with the Department of Gastroenterology, gastrointestinal Oncology and Endocrinology, University Medical Center Göttingen; PI: PD Alexander König, Department of Gastroenterology, gastrointestinal Oncology and Endocrinology, University Medical Center Göttingen
  • AIO-PAK-0219 METAPANC - Intensified treatment in patients with local operable but oligometastatic pancreatic cancer - multimodal surgical treatment versus systemic chemotherapy alone: a randomized controlled trial (funded by DFG)
    Collaboration with the Clinic for General, Visceral and Pediatric Surgery, University Medical Center Göttingen; PI: Prof B. Michael Ghadimi, Clinic for General, Visceral and Pediatric Surgery, University Medical Center Göttingen and Prof Jens T. Siveke, Clinic for Internal Medicine (Tumor Research), University Hospital Essen
  • PoR - Prospective comparative evaluation of the effectiveness of oncological follow-up rehabilitation in rehabilitants with breast cancer (funded by DRV)
    Collaboration with Working Group on Oncological Rehabilitation and Social Medicine (AGORS) of the German Cancer Society (DKG); PI: Prof Oliver Rick, MVZ for Hematology and Oncology Waldeck-Frankenberg GmbH

General Medicine and Health Service Research

  • REMEDI4ALL - Building a sustainable European innovation platform to enhance the repurposing of medicines for all (funded by EU - Horizon)
    Collaboration with Department of Paediatrics and Adolescent Medicine, University Medical Center Göttingen; Led by EATRIS, the European infrastructure for translational medicine with 24 European organisations closely collaborating [more information]
  • HOPE – Evaluation of the modifiability of hospital hygiene standards with regard to climateprotection (funded by Innovation Fund for Health Service Research of the G-BA)
    Collaboration with Institute for Hospital Hygiene and Infectiology University Medical Center Göttingen; PI: Prof. Simone Scheithauer, Institute for Hospital Hygiene and Infectiology University Medical Center Göttingen
  • HerzCheck – Detection of Early Heart Failure with Telemedical Procedures in Structurally WeakRegions (funded by Innovation Fund for Health Service Research of the G-BA)
    Collaboration with the German Heart Center Berlin; PIs: Prof Kelle, Department of Internal Medicine Cardiology, German Heart Center Berlin
  • ESCAPE – Evaluation of a patient-centred biopsychosocial blended collaborative care pathway for the treatment of multi-morbid elderly patients (funded by EU – Horizon 2020)
    Coordinating institution: Syddansk Universitet (DK)
  • PRECOVERY - Prospectively Enhanced Recovery through Prehabilitation of Older Patients before Cardiac Interventions (funded by Innovation Fund for Health Service Research of the G-BA)
    Collaboration with Department of Geriatrics, University Medical Center Göttingen, PL: Prof Christine von Arnim, Department of Geriatrics, University Medical Center Göttingen

Further Subjects

  • DOUBLE PRO-TECT Alport - A confirmatory, multicenter, randomized, double-blind, placebo-controlled clinical trial to assess the effect of Dapagliflozin on the progression of chronic kidney disease in adolescents and young adult patients with Alport syndrome (funded by DFG)
    Collaboration with the Clinic for Nephrology and Rheumatology, University Medical Center Göttingen; PI: Prof. Oliver Groß, Clinic for Nephrology and Rheumatology, University Medical Center Göttingen
  • MyTabu - Internet-based Treatment Program for Community Supervision of Child Abusers (funded by BMBF)
    Collaboration with the Clinic of Psychiatry and Psychotherapy, University Medical Center Göttingen; PI: Prof Jürgen L. Müller and Dr Peter Fromberger, Department for Forensic Psychiatry and Psychotherapy, Clinic of Psychiatry and Psychotherapy, University Medical Centre Göttingen
  • Partner site project „Development of a Dynamical Platform of Mobile Apps to Support Behavioural Interventions in Secondary Prevention of Heart Failure“ (funded by DZHK)
    Collaboration with the Clinic for Psychosomatic Medicine and Psychotherapy , University Medical Center Göttingen; PI: Prof Christoph Herrmann-Lingen, Clinic for Psychosomatic Medicine and Psychotherapy , University Medical Center Göttingen
  • TOTO - Tonsillectomy versus tonsillotomy in children and adults with recurrent acute tonsillitis (funded by GB-A)
    (Department of Medical Statistics | Clinical Trial Unit UMG) Collaboration with the Clinic and Polyclinic for neck, nose and throat medicine, University Hospital Jena
  • The VICToRY Trial - VItamin C in Thermal injuRY: A feasibility study for a seamless adaptive phase II/III multi-center randomized trial (funded by DFG)
    Collaboration with the University Hospital Würzburg; PI: Prof Christian Stoppe, Department of Anesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg
  • VIROA - Transorbital electrical stimulation as a vision restoration tool in patients with significant optic atrophy due to primary open-angle glaucoma (funded by DFG)
    (Department of Medical Statistics | Clinical Trial Unit UMG) Collaboration with the Clinic for Clinical Neurophysiology and the Clinic for Ophthalmology, University Medical Center Göttingen; PI: Prof Andrea Antal, Clinic for Clinical Neurophysiology and Prof Michael P. Schittkowski, Clinic for Ophthalmology, University Medical Center Göttingen

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