Current Projects

Department of Medical Statistics

Further projects by subjects

Methodology

  • Bayes-CoV19 - Corona Crisis and Beyond – Perspectives for Science, Scholarship and Society (funded by VolkswagenStiftung)
    PI: Prof Tim Friede, Department of Medical Statistics of the University Medical Center Göttingen; Prof Frank Konietschke, Institute of Biometry and Clinical Epidemiology, Campus Charité Mitte; Prof Markus Pauly, TU Dortmund; Project duration: 2021–2023
  • Statistical Planning of Translational Research (funded by DFG)
    PI: Prof Tim Friede, Department of Medical Statistics of the University Medical Center Göttingen; Prof. Frank Konietschke, Institute of Biometry and Clinical Epidemiology, Campus Charité Mitte; Project duration: 2021–2023
  • Frailty Modelling for Multivariate Current Status Data with Applications in Epidemiology (funded by DFG)
    PI: PD Dr Steffen Unkel, Department of Medical Statistics of the University Medical Center Göttingen; Project duration: 2018–2021 [more information]
  • Valid Methods for Meta-Analyses with Few Studies and Small Sample Sizes (funded by DFG)
    PIs: Prof Tim Friede, Department of Medical Statistics of the University Medical Center Göttingen and Prof Markus Pauly, Head of the Chair Mathematical Statistics and Applications in Industry of the Technical University Dortmund; Project duration: 2019–2022 [more information]
  • Partner site project „Information and Data Management“ (funded by DZHK)
    Collaboration with the Department of Medical Informatics of the University Medical Center Göttingen and the German Center for Cardiovascular Research (DZHK); PIs: Prof Tim Friede, Department of Medical Statistics, Prof Dagmar Krefting, Department of Medical Informatics of the University Medical Center Göttingen; Project duration: 2019–2020

Neurology

  • PROMISE - Prediction of Disease Activity Under Immunotherapy in People with Relapsing-remitting Multiple Sclerosis – A Systematic Review and Meta-analysis (funded by BMBF)
    Collaboration with the Institute for Neuroimmunology and Multiple Sclerosis (INIMS), UKE Hamburg; PI: Prof Christoph Heesen, Institute for Neuroimmunology and Multiple Sclerosis (INIMS), UKE Hamburg
  • Vorino-Stat – Multicenter Open Phase Ib Dose Escalation Study and Dose Confirmation Study on Tolerance and Safety of N-hydroxy-N'-phenyl-octanediamide in Patients with Mild Alzheimer’s Disease (funded by Alzheimer Stiftung Göttingen)
    Collaboration with the German Center for Neurodegenerative Diseases (DZNE)
  • Mino-TRD - Adjunct Minocycline in Treatment-resistant Depression (funded by BMBF)
    Collaboration with the Charité Berlin; PI: Prof Isabella Heuser from the Department of Psychiatry of the Charité Berlin
  • MS Deprexis - Online Program to Reduce Depression in MS – a Phase III International Multicenter Randomized Controlled Trial (funded by National Multiple Sclerosis Society)
    Collaboration with the Department of Psychiatry, Charité Berlin; PI: Prof Stefan Gold, Department of Psychiatry, Charité Berlin
  • POWER@MS - Interactive Web Platform for Empowerment in Multiple Sclerosis (funded by Innovation fund for health service research of the G-BA)
    Collaboration with the Institute for Neuroimmunology and Multiple Sclerosis (INIMS), UKE Hamburg; PI: Prof Christoph Heesen, Institute for Neuroimmunology and Multiple Sclerosis (INIMS), UKE Hamburg
  • ROCK-ALS - Inhibition of Rho Kinase (ROCK) with Fasudil as Disease-modifying Treatment for ALS (funded by BMBF)
    Collaboration with the Department of Neurology, University Medical Center Göttingen; PI: Prof Paul Lingor, Department of Neurology, University Medical Center Göttingen [more inforamtion]
  • EmBioProMS - Explorative Study of Emerging Blood Biomarkers in Progressive Multiple Sclerosis (funded by DMSG)
    Collaboration with the Neurology Clinic, RKU and the Clinic for Neurology in Dietenbronn; PI: Dr Ahmed Abdelhak, Neurology Clinic, RKU and Prof Hayrettin Tumani; Clinic for Neurology in Dietenbronn
  • SIMCODE - Simvastatin Add-on to Escitalopram in Patients with Comorbid Obesity and Major Depression: A Randomized Controlled Trial (funded by BMBF)
    Collaboration with the Charité Berlin; PI: Prof Christian Otte, Department of Psychiatry and Psychotherapy of the Charité Berlin

Cardiology

  • Partnersite Digitalisation Project - External validation of machine learning based risk scores for TAVI interventions and establishment of data and model sharing for machine learning in the DZHK (funded by DZHK)
    Collaboration with the Clinic for Cardiology and Pneumology, University Medical Center Göttingen PIs: Prof Tim Seidler, Clinic for Cardiology and Pneumology and Dr. Andreas Leha, Department of Medical Statistics, University Medical Center Göttingen
  • COVID-PREVENT: Effect of anticoagulation therapy on clinical outcomes in COVID-19 (funded by Industry and DZHK)
    Collaboration with the Charité Berlin; PI: Prof Ulf Landmesser and Prof Ursula Rauch-Kroehnert, Department of Cardiology, Charité Berlin [more information]
  • BioVAT-HF - Safety and Efficacy of Induced Pluripotent Stem Cell-derived Engineered Human Myocardium as Biological Ventricular Assist Device in Terminal Heart Failure (funded by DZHK)
    Collaboration with the Institute of Pharmacology and Toxicology of the University Medical Center Göttingen; PI: , Prof Wolfram-Hubertus Zimmermann, Institute of Pharmacology and Toxicology of the University Medical Center Göttingen
  • Reduce MFA - Effect of anti-fibrotic therapy on regression of myocardial fibrosis after transcatheter aortic valve implantation (TAVI) in aortic stenosis patients with high fibrotic burden (funded by DZHK)
    Collaboration with the Department of Cardiology and Pneumology, University Medical Center Göttingen; PIs: Prof Puls and Prof Zeisberg, Department of Cardiology and Pneumology, University Medical Center Göttingen
  • VAD-Trial - Early Versus Emergency Left Ventricular Assist Device Implantation in Patients Awaiting Cardiac Transplantation and Reg-VAD - Prospective, Observational, Multicentre Registry of Patients Eligible for the VAD Trial who Chose not to Participate in the Intervention Trial (funded by DZHK)
    Collaboration with the German Center for Cardiovascular Research (DZHK); PIs: Prof Volkmar Falk and PD Dr. Christoph Knosalla from the German Heart Institute (DHZB) Berlin; Prof Gerd Hasenfuß, Heart Center Göttingen and Prof Tim Friede, Department of Medical Statistics of the University Medical Center Göttingen [more information]
  • TransitionCHF Systolic Dysfunction to Congestive Heart Failure - Cohort Study (funded by DZHK)
    Collaboration with the Institute of Research on Myocardial Infarction (IHF GmbH) and the German Center for Cardiovascular Research (DZHK); PIs: Prof Gerd Hasenfuß, Prof Rolf Wachter and PD Dr. Frank Edelmann, Heart Center Göttingen, University Medical Center Göttingen [more information]
  • SPIRIT-DHF - SPIRonolactone In the Treatment for Diastolic Heart Failure (funded by DZHK)
    Collaboration with the Medical Department, Division of Cardiology, Charité University Medicine Berlin; PIs: Prof Burkert Pieske and PD Frank Edelman, Medical Department, Division of Cardiology, Charité University Medicine Berlin [more information]
  • RESHAPE-HF2 Trial - Randomised Investigation of the Mitraclip Device in Heart Failure: 2nd Trial in Patients with Clinically Significant Functional Mitral Regurgitation (funded by Industry)
    Collaboration with the Department of Innovative Clinical Trials, Heart Center of the University Medical Center Göttingen; PIs: Prof Wolfgang Schillinger, HELIOS Hospital Group and Prof Stefan Anker, Department of Innovative Clinical Trials, Heart Center of the University Medical Center Göttingen
  • FAIR-HF2 - Intravenous Iron in Patients with Systolic Heart Failure and Iron Deficiency to Improve Morbidity & Mortality (funded by DZHK)
    Collaboration with the Department of Innovative Clinical Trials, Heart Center of the University Medical Center Göttingen; PI: Prof Stefan Anker, Department of Innovative Clinical Trials of the University Medical Center Göttingen [more information]
  • CLOSURE-AF - Left Atrial Appendage CLOSURE in Patients with Atrial Fibrillation at High Risk of Stroke and Bleeding Compared to Medical Therapy: A Prospective Randomized Clinical Trial (funded by DZHK)
    Collaboration with the Department of Cardiology, Charité Berlin; PI: Prof Ulf Landmesser, Department of Cardiology, Charité Berlin [more information]
  • Ex-VAD - Exercise Training in Patients with Left Ventricular Assist Device (funded by DZHK)
    Collaboration with the Department of Cardiology, Charité Berlin; PI: Prof Burkert Pieske, Department of Cardiology, Charité Berlin [more information]
  • METRIS-HF - Effect of Metformin in Insulin Resistant Patients with Heart Failure with Reduced Ejection Fraction (funded by DZHK)
    Collaboration with the Center for Stroke Research and the Department of Cardiology, Charité Berlin and the Heart Center at the University Medical Center Göttingen; PI: Prof Wolfram Doehner, Department of Cardiology, Charité Berlin [more information]
  • DEDICATE - Randomized, Multi-Center, Event-Driven Trial of TAVI versus SAVR in Patients with Symptomatic Severe Aortic Valve Stenosis and Intermediate Risk of Mortality, as assessed by STS-Score (funded by DZHK)
    Sponsor Institution: University Medical Center Hamburg-Eppendorf (UKE); PIs: Prof Blankenberg, University Heart & Vascular Center Hamburg and Prof Cremer, Clinic for Cardiovascular Surgery, UKSH

Oncology

  • ACO/ARO/AIO-18.1 - Preoperative Oxaliplatin-based Chemoradiotherapy and Consolidation Chemotherapy Versus Fluorouracil-based Chemoradiotherapy for MRI-defined Intermediate and High-risk Rectal Cancer Patients (funded by DKH)
    Collaboration with the Department of Radiation Therapy and Oncology, University Hospital Frankfurt/Main; PI: Prof Claus Rödel, Department of Radiation Therapy and Oncology, University Hospital Frankfurt/Mai
  • ACO/ARO/AIO-18.2 - Preoperative FOLFOX Versus Postoperative Risk-adapted Chemotherapy in Patients With Locally Advanced Rectal Cancer (funded by DKH)
    Collaboration with the University Medical Center Mannheim; PI: Prof. Hofheinz, Mannheim Cancer Center

General Medicine and Health Service Research

  • InterprofHOME – Development and Evaluation of an Interprofessional Patient-centered Care Concept for Patients Living at Home (funded by Innovation Fund for Health Service Research of the G-BA)
    Collaboration with the Department of General Practice, University Medical Center Göttingen; PI Prof Hummers, Department of General Practice, University Medical Center Göttingen
  • DASI – Digitally Assisted Information Collection before Consultation (funded by Innovation Fund for Health Service Research of the G-BA)
    Collaboration with the Department of General Practice, University Medical Center Göttingen; PI Prof Hummers, Department of General Practice, University Medical Center Göttingen
  • HerzCheck – Detection of Early Heart Failure with Telemedical Procedures in Structurally Weak (funded by Innovation Fund for Health Service Research of the G-BA)
    Collaboration with the German Heart Center Berlin; PIs: Prof Kelle, Department of Internal Medicine Cardiology, German Heart Center Berlin
  • ESCAPE – Evaluation of a patient-centred biopsychosocial blended collaborative care pathway for the treatment of multi-morbid elderly patients (funded by EU – Horizon 2020)
    Coordinating institution: Syddansk Universitet (DK)
  • SCREBEL- Low-threshold screening versus multidimensional assessment of symptoms and psychosocial stress in cancer patients from the time of incurability (funded by Innovation Fund for Health Service Research of the G-BA)
    PI: Prof Alt-Epping, Clinic for Palliative Medicine, University Medical Center Göttingen
    Statistical design and analysis: Working group Biostatistics & Data Management in Clinical Trials (Department of Medical Statistics | Clinical Trial Unit UMG)
  • KOPAL - Development and Evaluation of a Concept for Cross-occupational Cooperation for Patients with Palliative Care Needs (funded by Innovation Fund for Health Service Research of the G-BA)
    Collaboration with the Department of General Practice / Primary Care, University Medical Center Hamburg-Eppendorf (UKE); PIs: Prof Scherer, Department of General Practice / Primary Care, University Medical Center Hamburg-Eppendorf (UKE), University Medical Center Hamburg-Eppendorf (UKE)
  • OPTINOFA - Optimization of the Emergency Care by Structured First Judgements with Intelligent Assistance Services (funded by Innovation fund for health service research of the G-BA)
    Collaboration with the Interdisciplinary Emergency Unit, University Medical Center Göttingen; PI: Prof Sabine Blaschke, Interdisciplinary Emergency Unit, University Medical Center Göttingen
  • UTI-IPD - Strategies to Reduce Antibiotic Use in Women with Uncomplicated Urinary Tract Infection Presenting to Primary Care - an Individual Patient Data Meta-Analysis (funded by BMBF)
    Collaboration with the Department of General Practice, University Medical Center Göttingen; PI: Prof Ildikó Gágyor, Department of General Practice, Faculty of Medicine Würzburg

Infectious Disease Medicine

  • AntiRedMen - Antiseptics for the reduction of nosocomial meningoventricular enteritis (funded by UMG)
    PI: Prof Simone Scheithauer, Department of Hospital Hygiene and Infectiology, University Medical Center Göttingen
    Statistical design and analysis: Working group Biostatistics & Data Management in Clinical Trials (Department of Medical Statistics | Clinical Trial Unit UMG

Further Subjects

  • MyTabu - Internet-based Treatment Program for Community Supervision of Child Abusers (funded by BMBF)
    Collaboration with the Clinic of Psychiatry and Psychotherapy, University Medical Center Göttingen; PI: Prof Jürgen L. Müller and Dr Peter Fromberger, Department for Forensic Psychiatry and Psychotherapy, Clinic of Psychiatry and Psychotherapy, University Medical Centre Göttingen
  • Partner site project „Development of a Dynamical Platform of Mobile Apps to Support Behavioural Interventions in Secondary Prevention of Heart Failure“ (funded by DZHK)
    Collaboration with the Clinic for Psychosomatic Medicine and Psychotherapy , University Medical Center Göttingen; PI: Prof Christoph Herrmann-Lingen, Clinic for Psychosomatic Medicine and Psychotherapy , University Medical Center Göttingen
  • TOTO - Tonsillectomy versus tonsillotomy in children and adults with recurrent acute tonsillitis (funded by GB-A)
    (Department of Medical Statistics | Clinical Trial Unit UMG) Collaboration with the Clinic and Polyclinic for neck, nose and throat medicine, University Hospital Jena

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