Prof. Dr. Martin Hellmich
Stellvertretender Institutsdirektor
Telefon: +49 551 3965022
Telefax: +49 551 39656055
E-Mail: martin.hellmich(at)med.uni-goettingen.de
Ort: Humboldtallee 32, EG 0.147
ORCID iD: 0000-0001-5174-928X
Kurzbiografie
[Seit 2025]
Wiss. Mitarbeiter / Stellv. Institutsdirektor, Institut für Medizinische Statistik, Universitätsmedizin Göttingen
[1998-2024]
Wiss. Mitarbeiter; seit 2015 Leitung der AG Medizinsche Statistik, Institut für Medizinische Statistik und Bioinformatik Medizinische Fakultät und Uniklinik Köln, Universität zu Köln
[2014]
Ernennung zum Außerplanmäßigen Professor
[2006]
Venia Legendi für das Fach „Medizinische Statistik“; Titel der Habilitationsschrift: „Statistische Methoden zur Bewertung medizinischer Tests für Diagnose und Prognose“
[1997]
Stipendiat des Deutschen Akademischen Austauschdienstes (DAAD) am Department of Epidemiology and Public Health, University of Leicester, UK
[1996]
Promotion zum „Dr. rer. medic.“ an der Medizinischen Fakultät der Westfälischen Wilhelms-Universität Münster; Titel der Dissertation: „Receiver Operating Characteristic (ROC) Kurven und Flächen darunter. Anwendungen in der Psychiatrie.“
[1994-1996]
Wiss. Mitarbeiter, Institut für Medizinische Informatik und Biomathematik, Westfälische Wilhelms-Universität Münster
[1987-1994]
Studium der Mathematik mit Nebenfach Logik, Westfälische Wilhelms-Universität Münster; Titel der Diplomarbeit (Schwerpunkt Funktionalanalysis): „Part-, Hilbert- und Hyperbolische Metrik“
Aktuell betreute Abschlussarbeiten
- Analysis of rescue medication and background therapy in randomized controlled trials (Ph.D.)
- Assessing efficacy and safety in clinical trials using structural equation modelling: applications to palliative care (Ph.D.)
- Statistical analysis of the Regression Discontinuity Design (RDD): Implications of combined or repeated measures (Ph.D.)
- Network meta-analysis to improve evidence based decision making in cancer research (Ph.D).
- Cologne Corona Surveillance (CoCoS) Study – eine prospektive populationsbasierte Kohortenstudie (Dr. med.)
Forschungsinteressen
- Methoden und Designs für die klinisch-epidemiologische Forschung
- multiple und adaptive Verfahren
- gemischte lineare Modelle und Strukturgleichungsmodelle
- Verfahren für Diagnose und Prognose
Publikationen
[2024]
Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial.
Kaasch AJ, López-Cortés LE, Rodríguez-Baño J, Cisneros JM, Dolores Navarro M, Fätkenheuer G, Jung N, Rieg S, Lepeule R, Coutte L, Bernard L, Lemaignen A, Kösters K, MacKenzie CR, Soriano A, Hagel S, Fantin B, Lafaurie M, Talarmin JP, Dinh A, Guimard T, Boutoille D, Welte T, Reuter S, Kluytmans J, Martin ML, Forestier E, Stocker H, Vitrat V, Tattevin P, Rommerskirchen A, Noret M, Adams A, Kern WV, Hellmich M, Seifert H; SABATO study group.
Lancet Infect Dis. 2024 May;24(5):523-534. doi: 10.1016/S1473-3099(23)00756-9. Epub 2024 Jan 17.
PMID: 38244557 Clinical Trial.
Evolutionary trajectories of small cell lung cancer under therapy.
George J, Maas L, Abedpour N, Cartolano M, Kaiser L, Fischer RN, Scheel AH, Weber JP, Hellmich M, Bosco G, Volz C, Mueller C, Dahmen I, John F, Alves CP, Werr L, Panse JP, Kirschner M, Engel-Riedel W, Jürgens J, Stoelben E, Brockmann M, Grau S, Sebastian M, Stratmann JA, Kern J, Hummel HD, Hegedüs B, Schuler M, Plönes T, Aigner C, Elter T, Toepelt K, Ko YD, Kurz S, Grohé C, Serke M, Höpker K, Hagmeyer L, Doerr F, Hekmath K, Strapatsas J, Kambartel KO, Chakupurakal G, Busch A, Bauernfeind FG, Griesinger F, Luers A, Dirks W, Wiewrodt R, Luecke A, Rodermann E, Diel A, Hagen V, Severin K, Ullrich RT, Reinhardt HC, Quaas A, Bogus M, Courts C, Nürnberg P, Becker K, Achter V, Büttner R, Wolf J, Peifer M, Thomas RK.
Nature. 2024 Mar;627(8005):880-889. doi: 10.1038/s41586-024-07177-7. Epub 2024 Mar 13.
PMID: 38480884 Free PMC article.
Transcatheter Repair versus Mitral-Valve Surgery for Secondary Mitral Regurgitation.
Baldus S, Doenst T, Pfister R, Gummert J, Kessler M, Boekstegers P, Lubos E, Schröder J, Thiele H, Walther T, Kelm M, Hausleiter J, Eitel I, Fischer-Rasokat U, Bufe A, Schmeisser A, Ince H, Lurz P, von Bardeleben RS, Hagl C, Noack T, Reith S, Beucher H, Reichenspurner H, Rottbauer W, Schulze PC, Müller W, Frank J, Hellmich M, Wahlers T, Rudolph V; MATTERHORN Investigators.
N Engl J Med. 2024 Nov 14;391(19):1787-1798. doi: 10.1056/NEJMoa2408739. Epub 2024 Aug 31.
PMID: 39216093 Clinical Trial.
Positive Vasoreactivity Testing in Pulmonary Arterial Hypertension: Therapeutic Consequences, Treatment Patterns, and Outcomes in the Modern Management Era.
Gerhardt F, Fiessler E, Olsson KM, Kayser MZ, Kovacs G, Gall H, Ghofrani HA, Badr Eslam R, Lang IM, Benjamin N, Grünig E, Halank M, Lange TJ, Ulrich S, Leuchte H, Held M, Klose H, Ewert R, Wilkens H, Pizarro C, Skowasch D, Wissmüller M, Hellmich M, Olschewski H, Hoeper MM, Rosenkranz S.
Circulation. 2024 May 14;149(20):1549-1564. doi: 10.1161/CIRCULATIONAHA.122.063821. Epub 2024 Apr 12.
PMID: 38606558
SARS-CoV-2 Test-to-Stay in Daycare.
Dewald F, Steger G, Fish I, Torre-Lage I, Hellriegel C, Milz E, Kolb-Bastigkeit A, Heger E, Fries M, Buess M, Marizy N, Michaelis B, Suárez I, Rubio Quintanares GH, Pirkl M, Aigner A, Oberste M, Hellmich M, Wong A, Orduz JC, Fätkenheuer G, Dötsch J, Kossow A, Moench EM, Quade G, Neumann U, Kaiser R, Schranz M, Klein F.
Pediatrics. 2024 May 1;153(5):e2023064668. doi: 10.1542/peds.2023-064668.
PMID: 38596855
Glutamate Signaling in Patients With Parkinson Disease With REM Sleep Behavior Disorder.
Doppler CEJ, Seger A, Farrher E, Régio Brambilla C, Hensel L, Filss CP, Hellmich M, Gogishvili A, Shah NJ, Lerche CW, Neumaier B, Langen KJ, Fink GR, Sommerauer M.
Neurology. 2024 May 14;102(9):e209271. doi: 10.1212/WNL.0000000000209271. Epub 2024 Apr 17.
PMID: 38630966
Potential of GPT-4 for Detecting Errors in Radiology Reports: Implications for Reporting Accuracy.
Gertz RJ, Dratsch T, Bunck AC, Lennartz S, Iuga AI, Hellmich MG, Persigehl T, Pennig L, Gietzen CH, Fervers P, Maintz D, Hahnfeldt R, Kottlors J.
Radiology. 2024 Apr;311(1):e232714. doi: 10.1148/radiol.232714.
PMID: 38625012
Inhibition of myeloperoxidase to treat left ventricular dysfunction in non-ischaemic cardiomyopathy.
Geissen S, Braumann S, Adler J, Nettersheim FS, Mehrkens D, Hof A, Guthoff H, von Stein P, Witkowski S, Gerdes N, Tellkamp F, Krüger M, Isermann L, Trifunovic A, Bunck AC, Mollenhauer M, Winkels H, Adam M, Klinke A, Buch G, Ten Cate V, Hellmich M, Kelm M, Rudolph V, Wild PS, Rosenkranz S, Baldus S.
Eur J Heart Fail. 2024 Oct;26(10):2269-2281. doi: 10.1002/ejhf.3435. Epub 2024 Aug 30.
PMID: 39212229
Perinatal photoperiod associations with bipolar disorder and depression: A systematic literature review and cross-sectional analysis of the UK Biobank database.
Lewis P, Gottlieb JF, Morfeld P, Hellmich M, Erren TC.
Psychiatry Res. 2024 May;335:115878. doi: 10.1016/j.psychres.2024.115878. Epub 2024 Mar 26.
PMID: 38581863 Review.
Perceived Physical Health and Cognitive Behavioral Therapy vs Supportive Psychotherapy Outcomes in Adults With Late-Life Depression: A Secondary Analysis of a Randomized Clinical Trial.
Dafsari FS, Bewernick B, Böhringer S, Domschke K, Elsaesser M, Löbner M, Luppa M, Schmitt S, Wingenfeld K, Wolf E, Zehender N, Hellmich M, Müller W, Wagner M, Peters O, Frölich L, Riedel-Heller S, Schramm E, Hautzinger M, Jessen F.
JAMA Netw Open. 2024 Apr 1;7(4):e245841. doi: 10.1001/jamanetworkopen.2024.5841.
PMID: 38619842 Free PMC article. Clinical Trial.
Palliative care for in-patient malignant glioma patients in Germany.
Fink L, van Oorschot B, von Saß C, Dibué M, Foster MT, Golla H, Goldbrunner R, Senft C, Lawson McLean A, Hellmich M, Dinc N, Voltz R, Melching H, Jungk C, Kamp MA.
J Neurooncol. 2024 Apr;167(2):323-338. doi: 10.1007/s11060-024-04611-8. Epub 2024 Mar 20.
PMID: 38506960 Free PMC article.
Flucloxacillin and cefazolin for treatment of Staphylococcus aureus bloodstream infection.
Schmidt-Hellerau K, Breuninger M, Kessel J, Vehreschild MJGT, Paul G, Reusch J, Jung N, Hellmich M, Fätkenheuer G.
Infection. 2024 Jun;52(3):1159-1163. doi: 10.1007/s15010-023-02168-8. Epub 2024 Jan 31.
PMID: 38296936 Free PMC article.
Hydrochlorothiazide and increased risk of atypical fibroxanthoma and pleomorphic dermal sarcoma.
Kuntz T, Grimm A, Hofmann SC, Michalowitz AL, Schaller J, Hellmich M, Assaf C, Oellig F, Kreuter A.
J Dtsch Dermatol Ges. 2024 Apr;22(4):513-519. doi: 10.1111/ddg.15379. Epub 2024 Mar 14.
PMID: 38483049
Transcatheter Repair Versus Surgery for Atrial Versus Ventricular Functional Mitral Regurgitation - a Post-hoc Analysis of the MATTERHORN Trial.
Rudolph F, Geyer M, Baldus S, De Luca VM, Doenst T, Pfister R, Gummert J, Kessler M, Boekstegers P, Lubos E, Schröder J, Thiele H, Walther T, Kelm M, Hausleiter J, Eitel I, Fischer-Rasokat U, Bufe A, Schmeisser A, Ince H, Lurz P, von Bardeleben RS, Hagl C, Noack T, Reith S, Beucher H, Reichenspurner H, Rottbauer W, Schulze PC, Müller W, Frank J, Michalik C, Hellmich M, Wahlers T, Rudolph V, Iliadis C.
Circulation. 2024 Oct 30. doi: 10.1161/CIRCULATIONAHA.124.072648. Online ahead of print.
PMID: 39475706 No abstract available.
Low incidence of acute kidney injury in VLBW infants with restrictive use of mechanical ventilation.
Burgmaier K, Zeiher M, Weber A, Cosgun ZC, Aydin A, Kuehne B, Burgmaier M, Hellmich M, Mehler K, Kribs A, Habbig S.
Pediatr Nephrol. 2024 Apr;39(4):1279-1288. doi: 10.1007/s00467-023-06182-8. Epub 2023 Nov 13.
PMID: 37955704 Free PMC article.
Outpatient parenteral antimicrobial therapy (OPAT) in Germany: insights and clinical outcomes from the K-APAT cohort study.
Schmidt-Hellerau K, Baade N, Günther M, Scholten N, Lindemann CH, Leisse C, Oberröhrmann C, Peter S, Jung N, Suarez I, Horn C, Ihle P, Küpper-Nybelen J, Hagemeier A, Hellmich M, Lehmann C.
Infection. 2024 Aug;52(4):1407-1414. doi: 10.1007/s15010-024-02199-9. Epub 2024 Mar 13.
PMID: 38478255 Free PMC article.
2-Step Scores with optional nephropathology for the prediction of adverse outcomes for brain-dead donor kidneys in Eurotransplant.
Ernst A, Regele H, Chatzikyrkou C, Dendooven A, Turkevi-Nagy S, Tieken I, Oberbauer R, Reindl-Schwaighofer R, Abramowicz D, Hellemans R, Massart A, Ljubanovic DG, Senjug P, Maksimovic B, Aßfalg V, Neretljak I, Schleicher C, Clahsen-van Groningen M, Kojc N, Ellis CL, Kurschat CE, Lukomski L, Stippel D, Ströhlein M, Scurt FG, Roelofs JJ, Kers J, Harth A, Jungck C, Eccher A, Prütz I, Hellmich M, Vasuri F, Malvi D, Arns W, Becker JU.
Nephrol Dial Transplant. 2024 Dec 20;40(1):83-108. doi: 10.1093/ndt/gfae093.
PMID: 38632055
Overall survival and central nervous system activity of crizotinib in ROS1-rearranged lung cancer-final results of the EUCROSS trial.
Michels S, Massutí B, Vasyliv I, Stratmann J, Frank J, Adams A, Felip E, Grohé C, Rodriguez-Abreu D, Bischoff H, Carcereny I Costa E, Corral J, Pereira E, Fassunke J, Fischer RN, Insa A, Koleczko S, Nogova L, Reck M, Reutter T, Riedel R, Schaufler D, Scheffler M, Weisthoff M, Provencio M, Merkelbach-Bruse S, Hellmich M, Sebastian M, Büttner R, Persigehl T, Rosell R, Wolf J.
ESMO Open. 2024 Feb;9(2):102237. doi: 10.1016/j.esmoop.2024.102237. Epub 2024 Feb 12.
PMID: 38350336 Free PMC article.
Personalized, interdisciplinary patient pathway for cross-sector care of multimorbid patients (eliPfad trial): study protocol for a randomized controlled trial.
Lindemann CH, Burst V, Völker LA, Brähler S, Simic D, Becker I, Hellmich M, Kurscheid C, Scholten N, Krauspe R, Leibel K, Stock S, Brinkkoetter PT.
Trials. 2024 Mar 11;25(1):177. doi: 10.1186/s13063-024-08026-8.
PMID: 38468319 Free PMC article.
Reduction of contrast medium for transcatheter aortic valve replacement planning using a spectral detector CT: a prospective clinical trial.
Langenbach IL, Langenbach MC, Mayrhofer T, Foldyna B, Maintz D, Klein K, Wienemann H, Krug KB, Hellmich M, Adam M, Naehle CP.
Eur Radiol. 2024 Jun;34(6):4089-4099. doi: 10.1007/s00330-023-10403-x. Epub 2023 Nov 18.
PMID: 37979008 Free PMC article. Clinical Trial.
"So at least now I know how to deal with things myself, what I can do if it gets really bad again"-experiences with a long-term cross-sectoral advocacy care and case management for severe multiple sclerosis: a qualitative study.
Müller A, Hebben F, Dillen K, Dunkl V, Goereci Y, Voltz R, Löcherbach P, Warnke C, Golla H; COCOS-MS trial group represented by Martin Hellmich.
BMC Health Serv Res. 2024 Apr 10;24(1):453. doi: 10.1186/s12913-024-10851-1.
PMID: 38600493 Free PMC article.
Which trial do we need? Shorter antifungal treatment for candidemia - challenging the 14-day dogma.
Bekaan N, Cornely OA, Friede T, Prattes J, Sprute R, Hellmich M, Koehler P, Salmanton-García J, Stemler J, Reinhold I.
Clin Microbiol Infect. 2024 Sep 7:S1198-743X(24)00435-X. doi: 10.1016/j.cmi.2024.09.004. Online ahead of print.
PMID: 39251133 No abstract available.
Reply to: The puzzles surrounding the impact of face masks on 6-minute walking distance in pulmonary hypertension.
Wissmüller M, Wartner V, Hohmann C, Adler J, Kramer T, Hellmich M, Gerhardt F, Baldus S, Rosenkranz S.
Eur Respir J. 2024 May 16;63(5):2400529. doi: 10.1183/13993003.00529-2024. Print 2024 May.
PMID: 38754949 No abstract available.
Differential Psychological Treatment Effects in Patients With Late-Life Depression and a History of Childhood Maltreatment.
Müller J, Elsaesser M, Müller W, Hellmich M, Hammen M, Zehender N, Riedel-Heller S, Bewernick BH, Wagner M, Frölich L, Peters O, Dafsari FS, Domschke K, Jessen F, Hautzinger M, Schramm E.
Am J Geriatr Psychiatry. 2024 Nov;32(11):1325-1336. doi: 10.1016/j.jagp.2024.05.006. Epub 2024 May 17.
PMID: 38824050 Clinical Trial.
The double awareness of the wish to hasten death and the will to live: A secondary analysis of outlier patients from a mixed-methods study.
Boström K, Dojan T, Hellmich M, Kremeike K, Voltz R.
Palliat Med. 2024 Oct;38(9):1042-1053. doi: 10.1177/02692163241269689. Epub 2024 Aug 16.
PMID: 39152645 Free PMC article.
Screening for affective dysregulation in school-aged children: relationship with comprehensive measures of affective dysregulation and related mental disorders.
Treier AK, Döpfner M, Ravens-Sieberer U, Görtz-Dorten A, Boecker M, Goldbeck C, Banaschewski T, Aggensteiner PM, Hanisch C, Ritschel A, Kölch M, Daunke A, Roessner V, Kohls G, Kaman A; ADOPT Consortium.
Eur Child Adolesc Psychiatry. 2024 Feb;33(2):381-390. doi: 10.1007/s00787-023-02166-z. Epub 2023 Feb 17.
PMID: 36800039 Free PMC article.
Cognitive stimulation for people with dementia in nursing homes: a protocol for a feasibility study examining a new 24/7 approach (CogStim24).
Folkerts AK, Seven ÜS, Guicheteau J, Dichter MN, Hellmich M, Köpke S, Kalbe E.
BMJ Open. 2024 May 9;14(5):e078369. doi: 10.1136/bmjopen-2023-078369.
PMID: 38724048 Free PMC article.
Results of the Cologne Corona Surveillance (CoCoS) project- a cross-sectional study: survey data on risk factors of SARS-CoV-2 infection, and moderate-to-severe course in primarily immunized adults.
Oberste M, Asenova T, Ernst A, Shah-Hosseini K, Schnörch N, Buess M, Rosenberger KD, Kossow A, Dewald F, Neuhann F, Hellmich M.
BMC Public Health. 2024 Feb 21;24(1):548. doi: 10.1186/s12889-024-17958-4.
PMID: 38383381 Free PMC article.
Assessment of affective dysregulation in children: development and evaluation of a semi-structured interview for parents and for children.
Treier AK, Labarga SZ, Ginsberg C, Kohl LT, Görtz-Dorten A, Ravens-Sieberer U, Kaman A, Banaschewski T, Aggensteiner PM, Hanisch C, Kölch M, Daunke A, Roessner V, Kohls G, Döpfner M; ADOPT consortium.
Child Adolesc Psychiatry Ment Health. 2024 Jun 20;18(1):75. doi: 10.1186/s13034-024-00762-8.
PMID: 38902809 Free PMC article.
Webcam technology on neonatal wards-examining the objective and subjective workload of nurses: a combined observational and survey study.
Müller HS, Becker-Peth M, Kuntz L; Neo-CamCare.
BMC Nurs. 2024 Jul 2;23(1):449. doi: 10.1186/s12912-024-02107-4.
PMID: 38956601 Free PMC article.
Determining the optimal frequency of SARS-CoV-2 regular asymptomatic testing: A randomized feasibility trial in a home care setting.
Butzmann J, Hellriegel-Nehrkorn A, Dilas M, Pohl R, Hellmich M, Apfelbacher CJ, Kaasch AJ.
PLoS One. 2024 Jul 3;19(7):e0303344. doi: 10.1371/journal.pone.0303344. eCollection 2024.
PMID: 38959206 Free PMC article. Clinical Trial.
N-Acetylcysteine and a Specialized Preventive Intervention for Individuals at High Risk for Psychosis: A Randomized Double-Blind Multicenter Trial.
Wasserthal S, Muthesius A, Hurlemann R, Ruhrmann S, Schmidt SJ, Hellmich M, Schultze-Lutter F, Klosterkötter J, Müller H, Meyer-Lindenberg A, Poeppl TB, Walter H, Hirjak D, Koutsouleris N, Fallgatter AJ, Bechdolf A, Brockhaus-Dumke A, Mulert C, Philipsen A, Kambeitz J.
Schizophr Bull Open. 2024 Feb 28;5(1):sgae005. doi: 10.1093/schizbullopen/sgae005. eCollection 2024 Jan.
PMID: 39144108 Free PMC article.
[Mental distress of intensive care staff in Germany during the COVID-19 pandemic. Results from the VOICE study].
Niecke A, Henning M, Hellmich M, Erim Y, Morawa E, Beschoner P, Jerg-Bretzke L, Geiser F, Baranowski AM, Weidner K, Mogwitz S, Albus C.
Med Klin Intensivmed Notfmed. 2024 Aug 7. doi: 10.1007/s00063-024-01164-6. Online ahead of print.
PMID: 39112595 German.
PRO-P: evaluating the effect of electronic patient-reported outcome measures monitoring compared with standard care in prostate cancer patients undergoing surgery-study protocol for a randomized controlled trial.
Al-Monajjed R, Albers P, Droop J, Fugmann D, Noldus J, Palisaar RJ, Ritter M, Ellinger J, Krausewitz P, Truß M, Hadaschik B, Grünwald V, Schrader AJ, Papavassilis P, Ernstmann N, Schellenberger B, Moritz A, Kowalski C, Hellmich M, Heiden P, Hagemeier A, Horenkamp-Sonntag D, Giessing M, Pauler L, Dieng S, Peters M, Feick G, Karger A; PRO-P study group.
Trials. 2024 Nov 12;25(1):754. doi: 10.1186/s13063-024-08579-8.
PMID: 39533412 Free PMC article.
Registration accuracy comparing different rendering techniques on local vs external virtual 3D liver model reconstruction for vascular landmark setting by intraoperative ultrasound in augmented reality navigated liver resection.
Sheriff NJ, Thomas M, Bunck AC, Peterhans M, Datta RR, Hellmich M, Bruns CJ, Stippel DL, Wahba R.
Langenbecks Arch Surg. 2024 Sep 3;409(1):268. doi: 10.1007/s00423-024-03456-z.
PMID: 39225933 Free PMC article.
Assignment of the biological value of solid breast masses based on quantitative evaluations of spectral CT examinations using electron density mapping, Zeffective mapping and iodine mapping.
Klein K, Schafigh DG, Wallis MG, Campbell GM, Malter W, Schömig-Markiefka B, Maintz D, Hellmich M, Krug KB.
Eur J Radiol. 2024 Feb;171:111280. doi: 10.1016/j.ejrad.2023.111280. Epub 2023 Dec 23.
PMID: 38219351
Psychometric properties of the parent-rated assessment scale of positive and negative parenting behavior (FPNE) in a German sample of school-aged children.
Holas V, Thöne AK, Dose C, Gebauer S, Hautmann C, Görtz-Dorten A, Kohl LT, Plück J, Treier AK, Banaschewski T, Ravens-Sieberer U, Rößner V, Hanisch C, Kölch M, Holtmann M, Becker K, Renner T, Geissler J, Wenning J, Huss M, Poustka L, Döpfner M; ADOPT, the ESCAlife consortia.
Child Adolesc Psychiatry Ment Health. 2024 Dec 16;18(1):157. doi: 10.1186/s13034-024-00850-9.
PMID: 39681854 Free PMC article.