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Department of Medical Statistics
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In 2024 the "German University Medicine Award" goes to research team for the "heart patch"
This year's "Preis der Deutschen Hochschulmedizin" is being awarded to the team of scientists from the BioVAT-HF-DZHK20 translational study for a globally unique approach: The "heart patch" uses stem cells to repair the heart muscle and is intended to strengthen the heart permanently.
The Department of Medical Statistics is responsible for the biometric supervision and analysis of the study.
Find here the UMG press release.
AI-based prognostic models - can they be used in clinical practice?
In the EbM column from 25 September 2024, Maxi Schulz and Tim Mathes look at the requirements for using (AI-based) prognostic models in practice.
The article provides an overview of the criteria that a prognostic model must fulfil in order to be considered relevant and trustworthy. In addition, aspects for the successful implementation of a forecasting model are considered and the specifics and challenges for AI-based models are examined in more detail.
To article Requirements for the use of (AI-based) forecasting models in practice [PDF, DE]
Federated AI learning in cardiovascular medicine
In an interview in the current issue of E-HEALTH-COM, Prof Sandy Engelhardt (UK Heidelberg) reports on new perspectives for medical AI research and in this context on the AI/ML project group of the German Centre for Cardiovascular Research (DZHK), which was set up on the initiative of Prof Tim Friede, as well as on the joint project ‘ECG Federated Learning of TAVI Outcomes’, which is funded by the DZHK.
Find the full interview here.
Federated trained AI: Section through the aortic valve with its three valve pockets (reference E-HEALTH-COM; publication date: 12/09/2024)
Results of the RESHAPE-HF2 study published
The Department of Medical Statistics (Prof. Dr. Tim Friede and Dr. Marius Placzek) was involved in the analysis of the international study on the use of the MitraClip device in heart failure patients. The results of the study were presented at the congress of the European Society of Cardiology in London and published simultaneously in the New England Journal of Medicine.
You can find the joint press release from the UMG and Charité - Universitätsmedizin Berlin here.
Post-COVID syndrome: BMBF-funded trial starts
RAPID_REVIVE (Randomised Adaptive Assessment of Post COVID Syndrome Treatments_Reducing Inflammatory Activity in Patients with Post COVID Syndrome) is an adaptive, randomised, placebo-controlled and double-blind clinical phase 2 study sponsored by Goethe University and funded by the Federal Ministry of Education and Research (BMBF) as part of the University Medicine Network.
The structural requirements for the start of the study were created as part of the NUM project ‘NAPKON Therapeutic Intervention Platform’ (NAPKON-TIP), in which the Department of Medical Statistics is involved.
To the press release of Goethe University Frankfurt am Main.
Symposium "Recent Advances in Meta-Analysis"
A symposium on the latest developments in meta-analysis methods was held in Göttingen on 28th and 29th of August 2024
Find here the programme of the symposium.
How evidence-based medicine helps MS patients
In a one-hour podcast, Tim Friede talks about evidence-based medicine and what it means for people with multiple sclerosis.
The article is part of Nele Handwerker's blog and can be listened to at the following link:
https://ms-perspektive.de/255-tim-friede [DE]
First conference of German AI service centres in Göttingen
KonKIS - the first conference of German AI service centres - will take place on 18-19 September 2024 in Göttingen. This year's focus is on AI in healthcare and the energy industry. The conference is aimed at researchers and interested parties from science and industry, especially from small and medium-sized enterprises with a need for computing power and AI expertise.
The Department of Medical Statistics is involved in setting up the AI service centre KISSKI (Hanover/Göttingen/Kassel) and will give a presentation at the conference on the challenges of introducing AI-based prediction models into medical practice.
Tim Mathes board member of the EbM network
Prof Dr Tim Mathes was elected as second deputy chairman in the board of the Network for Evidence-Based Medicine on 14 March 2024.
The EbM Network sees itself as the German-speaking competence and reference centre for all aspects of evidence-based medicine. It brings together representatives from various disciplines, professions, sectors and organisations and provides a space for independent, critical and scientific discussions on all issues relating to evidence-based healthcare.
More information on the board election [DE].
Symposium "Statistical Planning of Translational Studies"
On 20 and 21 March 2024, a symposium on current methods for statistical planning of translational studies took place in Göttingen.
Programme and download of Presentations: "Statistical Planning of Translational Studies"
Awarding of the Susanne Dahms Medal
Tim Friede was awarded the Susanne Dahms Medal for his outstanding accomplishments for the International Biometric Society and its German Region (IBS-DR) at the 70th Biometric Colloquium in Lübeck on 29 February 2024.
Read here the current UMG press release [DE].
The German Centre for Cardiovascular Research (DZHK), for which Tim Friede works as Principal Investigator at the DZHK site in Göttingen, has also responded to the award with a press release.
In it, the DZHK vividly describes the importance of biometrics for clinical studies.
To the DZHK press release [EN].
Final result of the DFG review board election – Tim Friede is a new member
On 27 February 2024, the final result of the review board election 2023 was determined.
Tim Friede was appointed by the President of the German Research Foundation as a newly elected member for the subject 2.22-01 "Epidemiology and Medical Biometry/Statistics" in Review Board 2.22 "Medicine" for the coming term of office 2024-2028.
New at the UMG – Introduction of the Service Group "Systematic Reviews and Meta-Analyses"
The Service Group "Systematic Reviews and Meta-Analyses" is intended to provide methodological counseling for evidence synthesis products (e.g. clinical practice guidelines, systematic reviews, rapid reviews) for scientists and clinicians at the UMG.
This includes, support with systematic literature searches, data extraction, assessment of methodological quality and meta-analyses, according the national (e.g. AWMF) and international standards (e.g. Cochrane).
Prof Tim Mathes, head of the Service Group, will present the services in a virtual lunch meeting and answer your questions.
You can participate in the meetings under the following links:
- Thursday 07.03.2024, 13:30 to 14:00:
https://uni-goettingen.zoom-x.de/j/61811765145 - Wednesday 20.03.2024, 12:30 to 13:00:
https://uni-goettingen.zoom-x.de/j/61703254729
Further information on the Service Group can be found here: Systematic Reviews and Meta-Analyses
The Department of Medical Statistics mourns the death of Reinhard Hilgers
The Department of Medical Statistics mourns the loss of Prof Dr Reinhard Hilgers, who passed away on 30 January 2024. For over 45 years, he helped shape the fortunes of the Department and medical biometrics at the Göttingen site in research, teaching and statistical consulting. Sadly, we must now bid farewell to a valued colleague and recognised expert in the field of biometrics.
We would like to convey our sincere sympathy and condolences to his family in these difficult times.
On behalf of all current and former members of the Department:
Prof Dr Tim Friede (Director) and Prof Dr Edgar Brunner (Director Emeritus) of the Department of Medical Statistics
New methodological procedure enables more precise summary of study results
The Department of Medical Statistics and the independent Institute for Quality and Efficiency in Health Care (IQWiG) have developed a new methodological procedure that allows the benefits of medical treatment measures to be assessed more reliably than before, in particular, if only few studies are available.
Read the joint press release [DE] from 22 January 2024.
"20 Years of Clinical Trials: Success, Impulses, Perspectives"
To mark the anniversary of the funding programme, the DFG and BMBF invited experts in clinical research on 9 November 2023 to the Berlin-Brandenburg Academy of Sciences and Humanities.
An opportunity for Professor Dr Tim Friede to highlight the importance of good biometric study planning and provide insights into innovative biometrical approaches for sample size planning and randomisation.
More information about the event [DE].
Symposium "Recent Advances in Meta-Analysis: Methods and Software"
In August 2023 a symposium on current methods and software tools for meta-analyses was held in Göttingen. It was initiated by Tim Friede, Christian Röver (Department of Medical Statistics, University Medical Center Göttingen) and Markus Pauly (Department of Statistics, TU Dortmund University) and took place as part of a German Research Foundation project.
The programme included presentations of many renowned researchers in the field of meta-analysis and a practical introduction to the current software.
See here the presentations of the speakers: "Recent Advances in Meta-Analysis: Methods and Software"
IGeL Podcast: Special episode "Evidence instead of eminence"
On the occasion of the 25th anniversary of the "Netzwerk evidenzbasierte Medizin" (ebM), Prof. Tim Mathes, elected assessor of the ebM board, can be heard in this special podcast.
Together with Prof. Günter Ollenschläger, founding member of ebM, he talks about how evidence-based medicine has fundamentally changed the health system and what demands will continue to be placed on the health system.
To the podcast Evidence instead of eminence.
UTI-IPD project group receives the "David Sackett Prize 2023"
The team of the project group "UTI-IPD - Reducing antibiotic use in uncomplicated urinary tract infections in adult women: a systematic review and individual participant data meta-analysis" is this year's winner of the David Sackett Prize. UMG staff from the Department of Medical Statistics and the Department of General Practice and Family Medicine were involved in the project. The project was led by Prof. Dr. Ildikó Gágyor from the University Hospital of Würzburg.
The prize is awarded for outstanding scientific achievements in the field of evidence-based medicine and health care in research, teaching or in the dissemination of the concerns of EBM. The award ceremony took place during the EbM Network Annual Meeting from 22-24 March 2023 in Potsdam.
Find all information about the award ceremony (in German) and the work that was awarded here.
Interesting facts from the Medical Statistics
"Heart patch" - research into artificial heart muscle tissue (BioVAT-HF-DZHK20)
The Department of Medical Statistics and its study statistics team are involved in the BioVAT-HF study, which is led by the Department of Pharmacology and Toxicology and funded by the German Centre for Cardiovascular Research (DZHK). Within the study, the implantation of a "heart patch" with heart muscle tissue produced from stem cells is being tested for the first time worldwide in cases of heart failure.
The following video provides a brief overview of the study: "Herzpflaster“ - Forschung zu künstlichem Herzgewebe"
Discussion Paper "On the role of data, statistics and decisions in a pandemic"
This discussion paper was prepared with the participation of Prof. Tim Friede and published in the journal "Advances in Statistical Analysis".
The aim of this paper is to provide an overview of decision-making processes during a pandemic and to make recommendations on this from a statistical perspective.
Statement on the systematic review "The serotonin theory of depression"
In an article of the NZZ (Neue Zürcher Zeitung), Professor Friede comments on the systematic review "The serotonin theory of depression".
To article "Depressionen: "An den fehlenden Glückshormonen liegt’s doch nicht"