Abschlossene Projekte 2011–2021

Institut für Medizinische Statistik

Abgeschlossene Projekte nach Fachgebieten

Methodik

  • Identification and Confirmation of Biomarker-defined Populations in the Personalized Pharmacotherapy (supported by BfArM)
    Collaboration with the Federal Institute for Drugs and Medical Devices (BfArM) and the Department of Clinical Pharmacology of the University Medical Center Göttingen; PIs: Prof Tim Friede, Department of Medical Statistics and Prof Jürgen Brockmöller, Department of Clinical Pharmacology of the University Medical Center Göttingen and PD Dr Norbert Benda, BfArM and Prof Julia Stingl, Department of Pharmacology and Toxicology RWTH Aachen; Project duration: 2016-2019
  • Partner site project „Information and Data Management“ within the National Development of a Stem Cell-Information-System (funded by DZHK)
    Collaboration with the Department of Medical Informatics of the University Medical Center Göttingen and the German Center for Cardiovascular Research (DZHK); PIs: Prof Tim Friede, Department of Medical Statistics and Prof Otto Rienhoff, Department of Medical Informatics of the University Medical Center Göttingen; Project duration: 2011-2018
  • InSPiRe – Innovative Methodology for Small Populations Research; Work Package 4: Research in Use of Evidence Synthesis in the Planning and Interpretation of Clinical Trials in Small Populations and Rare Diseases (funded by EC)
    Collaboration with the Warwick University, INSERM Paris, Medical University Wien; PI: Prof Nigel Stallard, Division of Health Sciences, Warwick Medical School, Warwick University; PI WP 4: Prof Tim Friede, Department of Medical Statistics of the University Medical Center Göttingen; Project duration: 2014-2017
  • Blinded Sample Size Reestimation in Clinical Trials with Recurrent Event Data and Time-dependent Event Rates (funded by DFG)
    Collaboration with the Newcastle University and Novartis AG, Basel; PI: Prof Tim Friede, Department of Medical Statistics of the University Medical Center Göttingen; Project duration: 2012-2016
  • Joint Research Project 05M2013: Biostatistical Methods for Efficient Evaluation of Individualized Therapies (BIMIT) (funded by BMBF)
    Collaboration with the University Heidelberg, University Bremen and pharmaceutical industries; PIs: Prof Meinhard Kieser (project coordinator), Institute of Medical Biometry and Informatics of the University Heidelberg; Prof Werner Brannath, Competence Center for Clinical Trials of the University Bremen and Prof Tim Friede, Department of Medical Statistics of the University Medical Center Göttingen; Project duration: 2013-2016
  • Using Surrogate Endpoints for Decision-Making in Adaptive Seamless Designs (funded by UK MRC)
    Collaboration with the Warwick University, University of Reading; PI: Prof Nigel Stallard, Division of Health Sciences, Warwick Medical School, Warwick University; Project duration: 2011-2015
  • Analysis and Assessment of Dose-finding Studies with Model-based Dose Calibration (supported by BfArM)
    Collaboration with the Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte - BfArM); PIs: Prof Tim Friede, Department of Medical Statistics of the University Medical Center Göttingen; Dr Norbert Benda and Dr Jörg Zinserling, BfArM); Project duration: 2012-2014
  • MÄQNU: Multivariate Equivalence Tests and Noninferiority Tests for high-dimensional Endpoints (funded by BMBF)
    Collaboration with the University Magdeburg, the University of Heidelberg, Bayer Schering Pharma AG, Berlin, Novartis Pharma, and StatConsult GmbH; Project duration: 2010-2013
  • Simultaneous Confidence Intervals for Non-parametric Effects in Factorial Models (funded by DFG)
    Collaboration with the University Hannover; PIs: Prof Edgar Brunner from the Department of Medical Statistics of the University Medical Center Göttingen and Prof Ludwig Hothorn from the Department of Biostatistics of the University Hannover; Project duration: 2009-2013

Neurologie

  • Competence Network Multiple Sclerosis: Antibody Signatures as Diagnostic, Prognostic, and Therapy Response Markers in Pathologically Defined Multiple Sclerosis Patterns and Neuromyelitis Optica (funded by BMBF)
    Collaboration with the Institute for Neuropathology of the University Medical Center Göttingen and the Charité Berlin; PI: Dr. Imke Metz from the Institute for Neuropathology of the University Medical Center Göttingen; Project duration: 2013-2016
  • EuReMS – European Register for Multiple Sclerosis (funded by EC)
    Consortium of academic institutions and NGOs from different countries with the European MS Platform (EMSP) as main partner; Project duration: 2011-2014
  • Competence Network Degenerative Dementia (KNDD): Characterization of predictors for rapid progressive Alzheimer’s disease (funded by BMBF)
    Collaboration with the Department of Neurology, University Medical Center Göttingen; PI: Prof Inga Zerr, Department of Neurology, University Medical Center Göttingen; Consortium of academic institutions from Germany; Project duration: 2011-2014

Kardiologie

  • HFpEF-stress - Cardiovascular Magnetic Resonance Real Time Exercise Stress Testing in Heart Failure with Preserved Ejection Fraction (funded by DZHK)
    Collaboration with the Heart Center at the University Medical Center Göttingen; PI: PD Andreas Schuster, Department of Cardiology and Pneumology of the University Medical Center Göttingen
  • DYNAMIC-MR - Stress Testing and Echocardiography to Identify Significant Dynamic Mitral Valve Regurgitation Amenable to MitraClip Mitral Valve Repair in Patients with Heart Failure and Reduced Ejection Fraction (funded by DZHK)
    Collaboration with the Department of Cardiology, Charité Berlin; PI: Prof Burkert Pieske, Department of Cardiology, Charité Berlin
  • EU-CERT-ICD - Comparative Effectiveness Research to Assess the Use of Primary Prophylactic Implantable Cardioverter Defibrillators in Europe (funded by EC)
    Consortium of 19 European organisations; Consortium coordinator: Prof Markus Zabel from the Heart Center of the University Medical Center Göttingen; Project duration: 2013-2018
  • Next-Generation Sequencing and Susceptibility Phenotyping for Arrhythmia Risk Analysis in Patients (funded by DZHK)
    Collaboration with the Department of Cardiology and Pneumology of the University Medical Center Göttingen; PI: Prof Stephan Lehnart, Department of Cardiology and Pneumology of the University Medical Center Göttingen
  • Development of Real-Time Procedure for the Quantification of Flow Measurements in Heart Valves and Large Thoracic Blood Vessels with Magnetic Resonance Tomography in Healthy People and Patients with Different Valve Diseases (funded by DFG)
    Collaboration with the Department of Diagnostic and Interventional Radiology of the University Medical Center Göttingen, the BiomedNMR Forschungs GmbH of the Max-Planck-Institute, the Department of Cardiology and Pneumology and the Department of Pediatric Cardiology and Intensive Care Medicine of the University Medical Center Göttingen and the University of Berkeley; PIs: Prof Joachim Lotz, Department of Diagnostic and Interventional Radiology of the University Medical Center Göttingen and Prof Jens Frahm, BiomedNMR Forschungs GmbH; Project duration: 2012-2017
  • EUTrigTreat (funded by EC)
    Consortium of academic institutions and clinical centers from different European countries; Consortium coordinator: Prof Stephan Lehnart, Department of Cardiology and Pneumology, University Medical Center Göttingen; Project duration: 2009-2014

Onkologie

  • TransValid-KFO179/GRCSG-Trial (funded by DFG)
    Collaboration with the Department of General, Visceral and Pediatric Surgery of the University Medical Center Göttingen and the Department of Radiation Therapy and Oncology of the University Hospital Frankfurt; PI: PD Torsten Liersch and Prof Michael Ghadimi from the Department of General and Visceral Surgery, University Medical Center Göttingen
  • CAO/ARO/AIO-12 - Induction Chemotherapy Before or After Preoperative Chemoradiotherapy and Surgery for Locally Advanced Rectal Cancer: A Randomized Phase II Trial of the German Rectal Cancer Study Group (funded by DKH)
    Collaboration with Department of Radiation Therapy and Oncology of the University Hospital Frankfurt/M.; PI: Prof Claus Rödel, Department of Radiation Therapy and Oncology of the University Hospital Frankfurt/M.
  • Joint Research Project: MetastaSys - Analysis of Molecular Markers and Pathways in Cancer Cells and Microenvironment that Determine the Fate and Localization of Tumor Metastases (funded by BMBF)
    Collaboration with 8 partners from the University Medical Center Göttingen and the German Cancer Research Center (DKFZ); Project coordinators: Prof Tim Beißbarth, Department of Medical Statistics and Prof Lorenz Trümper, Department of Hematology and Medical Oncology of the University Medical Center Göttingen; Project duration: 2013-2016
  • Clinical Research Group (KFO 179) - Biological Basis of Individual Tumor Response in Patients with Rectal Cancer; Subproject 8: Development of Statistical and Computational Methods, Tools, and Infrastructure as well as Data Analysis, Data Management, and Support for Clinical Researchers (funded by DFG)
    Consortium of academic institutions from Germany; Consortium coordinator: Prof Michael Ghadimi, Department of General, Visceral and Pediatric Surgery of the University Medical Center Göttingen; PIs SP 8: Prof Tim Beißbarth, the Department of Medical Statistics and Prof Ulrich Sax, Department of Medical Informatics of the University Medical Center Göttingen; Project duration: 2008-2015
  • Research group (FOR 942) - Wnt Signaling in Development and Tumor Progression; Subproject 8: Bioinformatics Approach to Establish a New Graph-based Wnt Model for Metastasis Formation in Breast Cancer Cells (funded by DFG)
    Collaboration with 7 partners from the University Medical Center Göttingen and the University Erlangen; Consortium coordinator: Prof Lorenz Trümper, Department of Hematology and Medical Oncology of the University Medical Center Göttingen; PI SP 8: Prof Tim Beißbarth, Department of Medical Statistics of the University Medical Center Göttingen; Project duration: 2011-2014
  • BreastSys - Identifying Novel Therapeutic Strategies for Breast Cancer by Data-driven Modeling of Tumor Progression; Subproject: Data Management, Statistical Analysis and Qualitative Network Modelling (funded by BMBF)
    Collaboration with the German Cancer Research Center (DKFZ), the University of Freiburg, the Heidelberg University Hospital and Roche Diagnostics Mannheim; Consortium coordinator: Prof Tim Beißbarth, Department of Medical Statistics of the University Medical Center Göttingen; Project duration: 2008-2012
  • IG-Prostate Cancer: Translating Molecular Profiles into Enhanced Diagnosis of Clinically Significant Prostate Cancer; Subproject 13: Computational and Systems Biology (funded by BMBF)
    Collaboration with the German Cancer Research Center (DKFZ), the University Hamburg, the University Medical Center Hamburg-Eppendorf, the Martini-Klinik Hamburg and CAN GmbH, Hamburg; PI Subproject 13: Prof Tim Beißbarth, Department of Medical Statistics of the University Medical Center Göttingen within the National Genome Research Network (NGFN-Plus); Project duration: 2008-2011
  • IG-Cellular Systems Genomics: Cellular Systems Genomics in Health and Disease; Subproject 10: Integrated Network Modeling (funded by BMBF)
    Collaboration with German Cancer Research Center (DKFZ); PI Subproject 10: Prof Tim Beißbarth, Department of Medical Statistics of the University Medical Center Göttingen within the National Genome Research Network (NGFN-Plus); Project duration: 2008-2011
  • SB-Cancer: Systems-Biology of Signaling in Cancer; Subproject V.9: Analysis of RNAi and Screening Data to Identify Novel Network Components (funded by Helmholtz Society)
    Consortium of Helmholtz centers and external partners; PIs Subproject V.9: Prof Tim Beißbarth, Department of Medical Statistics of the University Medical Center Göttingen and Prof Michael Boutros form the German Cancer Research Center (DKFZ); Project duration: 2007-2012

Versorgungs- und Gesundheitsforschung

  • REGATTA - Reducing Antibiotic Use for Uncomplicated Urinary Tract Infection General Practice by Treatment with Uva Ursi - A Comparative Effectiveness Trial (funded by BMBF)
    Collaboration with the Department of General Practice, University Medical Center Göttingen; PI: Prof Eva Hummers, Department of General Practice, University Medical Center Göttingen
  • InterprofACT - Effects of Strategy to Improve the Cooperation Between Physician and Nurse Regarding Hospitalisation of Nursing Home Residents (funded by Innovation fund for health service research of the G-BA)
    Collaboration with the Department of General Practice, University Medical Center Göttingen; PI: Prof Hummers-Pradier, Department of General Practice, University Medical Center Göttingen

Nephrologie

  • KMU-innovativ-13: Validation of a cfDNA-based Diagnostic Test for the Early Detection of Transplant Damage in Renal Transplantation (funded by BMBF)
    Collaboration of the Institute of Pharmacology and the Department of Medical Statistics of the University Medical Center Göttingen; the Central Institute of Clinical Chemistry of the Clinical Center Stuttgart and Chronix Biomedical GmbH, Göttingen; PIs: Prof Ekkehard Schütz, Chronix Biomedical GmbH, Göttingen and Prof Michael Oellerich, Institute of Pharmacology of the University Medical Center Göttingen
  • EARLY PRO-TECT Alport: Early Prospective Therapy Trial to Delay Renal Failure in Children with Alport Syndrome (funded by BMBF)
    Collaboration with the Department of Nephrology and Rheumatology; PI: Prof Oliver Gross, Department of Nephrology and Rheumatology, University Medical Center Göttingen; Project duration: 2011-2018

Infektiologie

  • RetoCDiff - Reduction of the Number of Infections with Toxin Producing Clostridium difficile in Geriatric Clinics (funded by Innovation fund for health service research of the G-BA)
    Collaboration with the Geriatric Center, Evangeligical Hospital Göttingen-Weende (EKW); PI: Prof Roland Nau, Geriatric Center, Evangeligical Hospital Göttingen-Weende (EKW) und Department for Neuropathology, University Medical Center Göttingen
  • INSIST - Impact of the Neonatology Screening on Infection Prediction / Reduction of Transmission (funded by Innovation fund for health service research of the G-BA)
    Collaboration with the Central Department for Hospital Hygiene and Infectiology, University Medical Center Göttingen ; PI: Prof. Simone Scheithauer, Central Department for Hospital Hygiene and Infectiology, University Medical Center Göttingen

Weitere Bereiche

  • Effect of orthodontic therapy on facial expression and psychosocial well-being - a 4D pilot study (funded by DFG)
    PI: Dr Anja Quast, Clinic for Orthodontics , University Medical Center Göttingen
    Statistical design and analysis: Working group Biostatistics & Data Management in Clinical Trials (Department of Medical Statistics | Clinical Trial Unit UMG)
  • Joint Research Project: GenoPerspectiv – Managing Genomic High-throughput Data – Regarding Perspectives of the Clinic, Ethics, Law and Biomedical Information Technology; Subproject 3: Preparation of Genomic Data for Molecular Diagnosis (funded by BMBF)
    Collaboration with the Department of Medical Informatics, the Department of Medical Ethics and History of Medicine, the Department of Psychiatry and Psychotherapy, the Department of General, Visceral and Pediatric Surgery of the University Medical Center Göttingen, the Center for Medical Law of the University Göttingen and the University Hospital Munich; Consortium coordinator: Prof Ulrich Sax, Department of Medical Informatics of the University Medical Center Göttingen; PI SP 3: Prof Tim Beißbarth, Department of Medical Statistics of the University Medical Center Göttingen; Project duration: 2014-2017
  • Back Schools for Low Back Pain (funded by BMBF)
    Collaboration with the Division of Preventive Medicine, Department of Medicine, University of Alberta, Edmonton, Canada; the Pain Research and Nuffield Division of Anaesthetics, Nuffield Department of Clinical Neurosciences of the University of Oxford; PI: Prof Tim Friede, Department of Medical Statistics of the University Medical Center Göttingen; Project duration: 2014-2015
  • Improving Patient Choice in Treating Low Back Pain (IMPACT-LBP) (funded by UK NIH)
    Collaboration with the Warwick University; PI: Prof Martin Underwood, Clinical Trials Unit of the Warwick University; Project duration: 2010-2013
  • Improving Outcomes from the Treatment of Low Back Pain (funded by UK NIH)
    Collaboration with the Warwick University, University of Queensland, Brunel University London; PI: Prof Martin Underwood from the Clinical Trials Unit of the Warwick University; Project duration: 2010-2013
  • BAPI-LTx - Biomarker Assisted Personalized Immunosuppression Following Liver Transplantation (funded by BMBF)
    Collaboration with the Department of Clinical Pharmacology, the Department of Clinical Chemistry and the Department of Transplantation Surgery of the University Medical Center Göttingen and the Clinics for hepatobiliary surgery and transplantation surgery of the University Hospital Hamburg; Consortium coordinator: Prof Jürgen Brockmöller, Department of Clinical Pharmacology of the University Medical Center Göttingen; Project duration: 2012-2015

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